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Debotton Nir, Ph.D

nird@shenkar.ac.il 03-6019320

A lecturer of Materials Engineering for Medical Applications and the Head of the Pharmaceutical and Cosmetics Research Center at the Department of Chemical Engineering.

Dr Debotton is a licensed pharmacist and he  received his Ph.D (2010) from the School of Pharmacy at the Hebrew University of Jerusalem. Previous R&D manager of pharma companies.

Current research topics in Pharmaceutical Sciences include: Nanomedicine, Development of pharmaceutical formulations for drug delivery and drug targeting, Pharmacokinetics of drug delivery systems and nanoparticles, Biodegradable and biocompatible polymers, and Topical skin penetration of drugs.

Recent Publications of Dr. Debotton:

  • Nir Debotton and Arik Dahan. A mechanistic approach to understanding oral drug absorption in pediatrics: An overview of fundamentals. Drug Discov Today, 2014; 19(9): 1322-1336
  • Amit Badihi, Nir Debotton, Marina Frusic-Zlotkin, Yoram Soroka, Rami
  • Neuman, Simon Benita. Enhanced cutaneous bioavailability of dehydroepiandosterone mediated by nano-encapsulation. Journal of Control Release, 2014; 10(189): 65-71.
  • Nir Debotton, Simon Benita. Characterization and therapeutic applications of immunonanoparticles as targeted drug-delivery systems. (Eds) Nissim Garti, Idit Amar-Yuli, Nanotechnologies for solubilization and delivery in foods,cosmetics and pharmaceuticals, DESHtech publications Inc, 2012;  Chapter 10: 303-339.
  • Nir Debotton, Hagit Zer, Oshrat Harush-Frenkel, Marcela Parnes, Jean Kadouche and Simon Benita. A quantitative evaluation of the molecular binding affinity between a monoclonal antibody conjugated to a nanoparticle and an antigen by surface plasmon resonance. European Journal of Pharmaceutics and Biopharmaceutics, 2010; 74(2):148-56.
  • Nir Debotton, Oren Giladi, Marcela Parnes, and Simon Benita. Novel high content paclitaxel palmitate nanospheres for improved cancer treatment. Journal of Drug Delivery Science and Technology, 2009; 19(4):275-282.
  • Nir Debotton, Marcela Parnes, Jean Kadouche, Simon Benita. Overcoming the formulation obstacles towards targeted chemotherapy: in vitro and in vivo evaluation of cytotoxic drug loaded immunonanoparticles. Journal of Controlled Release, 2008; 127(3):219-230.
  • Oshrat Harush-Frenkel, Nir Debotton, Simon Benita and Yoram Altschuler. Targeting of nanoparticles to the clathrin-mediated endocytic pathway. Biochemical and Biophysical Research Communications, 2007; 353:26–32.

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